Multifunctional Nanoparticles in Diagnosis of Pancreatic Cancer Cells
21 April 2008A team of reseachers at the Multifunctional Nanoparticles in Diagnosis and Therapy of Pancreatic Cancer Platform Partnership have used quantum dots for diagnosis and investigation of Pancreatic Cancer cells. Research finding has been published in the Journal Advanced materials, where the team has claimed that they have produced two types of quantum dots, one emitted orange light and the other emitted red light.
Researchers attached red quantum rod and orange quantum rod to monoclonal antibodies that recognized mesothelin and binds Claudin - 4 proteins respectively. After adding these conjugated quantum rods to the pancreatic cells, growing in culture, investigators used standard fluorescence microscopy for spotting the optical levels of both the protein cells. The finding showed that the cell used receptor-mediated endocytosis process to took quantum rods and only cell uptake was specific to those targeted by quantum rod conjugated antibodies.
The research team was headed by Paras Prasad of the State University of New York. The work was supported by NCI’s Alliance for Nanotechnology in Cancer.
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