Nanoparticle created for Tumor Imaging
24 July 2008Researchers at Siteman Center of Cancer Nanotechnology Excellence have used a polymer having water-soluble and water insoluble regions for creating a new bialy shaped nanoparticle. When manganese was attached to the nanoparticle, a new type of tumor imaging agent was obtained. Although magnesium is generally used for boosting the magnetic resonance imaging signals, however the new nanoparticle help not only in tumor imaging but it can also used as therapeutic agent.
The research team was headed jointly by Dr. Gregory Lanza and Dr. Samuel Wickline of Washington University, have preferred magnesium over gadolinium. Recently, there is a debate on the use of gadolinium for its use in tumor imaging as it has a chance to damage kidney in some of the patients. Therefore magnesium-based nanoparticles are the best options for imaging and delivering medicines to the tumor cells.
Polmer polyethyleneimine self assembles to form a nanoparticles that has a bialy shape, as bialy seems to be perfect agent. It has a large surface area and therefore magnesium effectively work as a MRI contrast agent. The researchers with the help of minor chemical coupling reaction added vascular targeting molecules to the desired nanoparticles.
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