Nanoparticles for Wound Healing Applications

30 March 2012

Slow healing wounds affect large number of elderly people especially who suffers from diabetes, immune suppression and peripheral vascular disease. Slow healing or non-healing wounds often decrease the quality life in older men and women and in US alone more than 2.5 million people are affected with the problem.

Nitric Oxide has been found to critically influence the wound healing role and attempts have been made to administer Nitric Oxide (NO) around the wound areas.

Actually NO heals the wound through a complex process, which involves antimicrobial properties, modulation of platelets and vasodilatory effects, promotion of angiogenesis and administered NO has shown some goof effects, however the current administration process are not human friendly and at the same time, these are costly as well.

In a recent online issue of 6th March 2012 of Nanomedicine: Nanotechnology, Biology and Medicine, researchers from Albert Einstein College of Medicine claim that they have found a better solution for NO storage that can be used for treating slow healing wounds. Adam Freidman and his team has found that a nanoparticle platform compised of silane based sol-gel and sugar derived glasses can generate, store and deliver NO in a controlled and sustained manner and the research team has already utilized the technique in immuno-deficient mice. 

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