Nanoparticles that has potential to deliver Cancer Drug accurately

23 January 2012

A novel class of micelles has been synthesized by Kit Lam, Professor Department of Biochemistry and Molecular Medicine and his team at the US Davis and these micelles are called as dual-responsive boronate cross linked micelles (BCMs) and the research work is published in the recent issue of Angewandte Chemie. 

These micelles are nano-sized measuring about 25-50 nanometers and hold potential as nanocarriers for greater accuracy to deliver cancer drugs to the tumors. Researchers claim that these BCMs releases the medicine as soon as these come in contact with the acidic micro environment and thus the premature drug release can be prevented by selecting a reversible cross-linked nanocarrier.

Stimuli responsive cross-linked micelles (SCM) have been found very versatile in releasing the payload as soon as these get some specific triggers and the present system develop by researchers show a great promise to the treatment of cancer. It has been observed that nanoparticles can prematurely release drug, which can cause damage to the healthy cell and at the same time the cancer cells don’t get the medicine and hence they spread as usual.

SCM can better retain the payload and prevent the premature delivery of the drug and the new dual-responsive boronate cross-linked micelles that researchers have developed can actually act to a number of stimulating agents and can thus ensure that the drug is delivered in the right environment. These micelles due to boronic acid and catechol containing polymers are sensitive to the slight change of the pH of the environment.

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