Nanotechnology used for oral anticancer drug delivery
26 January 2009At present the anticancer drugs are administered through injections only and therefore the patients need to visit doctors for getting their treatments. The treatment causes inconvenience to hundreds of thousands of cancer patients across the globe and at the same time it is quite costly also.
Researchers at John Hopkins University School of Medicines, Department of Chemistry Delhi University India and University Medical Centre Utrecht, the Netherlands jointly have developed polymeric nanoparticles that can be used for delivering drug orally in future. Anirban Maitra of department of pathology, John Hopkins University School of Medicine and his colleagues have synthesized a polymeric nanoparticle composed of N-isopropylacrylamide, methylacrylate and acrylic acid in the molar ratio of 60:20:20.
The new nanoparticle that has been synthesized by researchers was found to have size distribution of less than 100 nanometer with low polydispersity and therefore the nanoparticles are useful in encapsulating a number of hydrophobic drugs. Once the nanoparticle encapsulates the drug, it can easily deliver the drug into blood stream through gastrointestinal treat cells.
Further toxicological studies on the polymeric nanoparticle were carried out on mice and there were no apparent toxicities were observed on as much as 500 mg/kg of the oral dosage of the polymeric nanoparticles for 4 weeks. The new nanoparticle was able to deliver the anticancer drug rapamycin to the human pancreatic tumors that was implanted in mice for carrying out the tests. The finding of the research is published in the journal Molecular Cancer Therapeutics.
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