Protein stabilized nanoparticles could enhance drug discovery
26 June 2009Protein plays a key role in drug discovery and understanding the structure of these molecules could significantly enhance the development of new stable and efficient drug. At present with the conventional technologies available, the drug development is very slow due to various conditions including the instability of protein.
Researchers at Birmingham and Warwick Universities have found that if the membrane protein is preserved, researchers can get more details about the structure of protein and other molecular information. This new discovery will lead to use more and ignored protein molecules for drug discovery. The researchers have published their finding in the online Journal of American Chemical Society.
Researchers used the styrene maleic acid lipid particles (SMALPs) for stabilizing membrane and found that SMALPs maintained the structure and enzyme activities of protein intact making it suitable for useful for virtually all lab applications. The technique of stabilizing protein using SMALPs is useful in enhancing the stability, activity and structural qualities of protein membranes.
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