Stickiness of gold nanoparticles could be used for producing protein

15 June 2010

Gold nanoparticles are tiny spheres of gold in the range of 1 to 100 nanometer and these nanoparticles have become useful in medicines. These nanoparticles have found many useful applications in modern medicine and drug-delivery system is the most common application.

Howeevr, the major disadvantage of gold nanoparticles is that they are sticky and due to their stickiness property, these nanoparticles also stick to many unintended particles and thus making them unsuitable for their designed task. MIT Researchers have now utilized the sticking properties of gold nanoparticles for enhancing in vitro translation. The research finding has recently been published in ACS Nano.

Researchers found that the due to the stickiness of the gold nanoparticles, researchers could produce double the amount of protein in vitro translation. Researcher Kimberly Hamed-Schifferli and her coworker initially set up translation inhibition, for stopping the production of harmful protein with the help of gold nanoparticles expecting that the large nanoparticle-DNA aggregates would block the translation. The research was funded by the Institute of Biomedical Imaging and Bioengineering.

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