Nanoscale tool capable to study single membrane protein
9 March 2008Scientists at Rockefellor’s Laboratory of Molecular Biology and Biochemistry have developed a new nanoscale tool that can allow scientists to study exactly a single protein on a cell having thousands of other proteins. The scientists have created a tiny tool that is 10,000 times smaller than a human hair and resembles like sushi roll.
professor Thomas Sarkar, head of the laboratory and his team has developed the Nanoscale Apolipoprotein Bound Bilayers (NABBs). The team claimed that with this new tool it is possible to control the receptor’s membrane environment and at the same time it is also possible to find its interaction with ligands, other protein or receptors.
The research team looked for the functions of individual G-protein coupled receptors (GPCRs). These are the transmembrane proteins involved in many diseases. The team used Apo A-1 from zebrafish (known as zap 1) and devised a method that helps in self assembling of these disc like nanoparticles by combining zap 1, lipids and extracted cellular membrane proteins. Researchers beleive that the tool can be beneficial for screening many new drugs.
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