Researchers develop nanotechnology based synthetic version of HDL cholesterol

12 January 2009

Cholesterol is an essential ingredient required by our cell and HDL do the transportation job and delivers cholesterol to the liver. High-density lipoprotein or HDL cholesterol can play an important role in reducing the high cholesterol levels. Therefore higher the levels of HDL cholesterol in our blood, lower is the risk of deadly heart disease, as the excess of cholesterol is deposited on our arteries and thereby reducing the normal blood flow.

There are medicines for reducing the bad cholesterol (LDL) or low-density lipoprotein, as well as you can control the LDL by your diet or exercise, however you can rarely find the medicines for increasing the good cholesterol or HDL and even if you find any medicine, these medicines have severe side effects.

Researchers now has published a research paper in the Journal of the American Chemical Society (JACS), where they claim that they have successfully developed a synthetic HDL cholesterol based on gold nanoparticles that resembles with natural HDL. The research was led by Dr. Shad Thexton, assistant professor of Urology, Northwestern’s Feinberh School of Medicine and researchers from Weinberg college of Art and Science also participated in the study.

Researchers took gold nanoparticle as core for the synthesis of HDL and after layering it through a lipid, further layer it with a protein called as APOAI, which occurs in natural HDL cholesterol. Researchers thus obtained a synthetic HDL cholesterol that has around 18 nm diamter and is much similar to the naturally occurring HDL cholesterol

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